Article
Podocytes from hypertensive and obese mice acquire an inflammatory, senescent, and aged phenotype.
American journal of physiology. Renal physiology - 1 Apr 2024
McKinzie Sierra R, Kaverina Natalya, Schweickart Robert Allen, Chaney Christopher P, Eng Diana G, Pereira Beatriz Maria Veloso, Kestenbaum Bryan, Pippin Jeffrey W, Wessely Oliver, Shankland Stuart J
Abstract excerpt
Patients with hypertension or obesity can develop glomerular dysfunction characterized by injury and depletion of podocytes. To better understand the molecular processes involved, young mice were treated with either deoxycorticosterone acetate (DOCA) or fed a high-fat diet (HFD) to induce hypertension or obesity, respectively. The transcriptional changes associated with these phenotypes were measured by unbiased...
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