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Effects of Polyunsaturated Fatty Acid Serum Levels on Vascular Dementia: A Two-Sample Mendelian Randomization Study.

Cerebrovascular diseases (Basel, Switzerland) - 1 Jan 2024

Chen Shanshan, Cong Ruyi, Chen Yongbo, Li Xiaoliang, Zhang Xiaoyu, Wang Guohua, Pang Xiuyu, Xing Weijia, Wang Youxin, Xu Xizhu

Abstract excerpt

INTRODUCTION: Several observational studies have indicated that polyunsaturated fatty acid serum levels (PUFAs) are associated with vascular dementia (VaD), but their causal relationships remain elusive. Therefore, we attempted to evaluate the causal effect of PUFAs on VaD in a two-sample Mendelian randomization (MR) analysis by using summary statistics from aggregated genome-wide association studies. METHODS:...

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PMID: 37482052
DOI: 10.1159/000531861

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