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Structures of dengue virus RNA replicase complexes

20 Jul 2023

Abstract excerpt

Dengue is a mosquito-borne viral infection caused by dengue virus (DENV), a member of the flaviviruses. The DENV genome is a 5'-capped positive-sense RNA with a unique 5'-stem-loop structure (SLA), which is essential for RNA replication and 5' capping. The virus-encoded proteins NS5 and NS3 are responsible for viral genome replication, but the structural basis by which they cooperatively conduct the required...

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PMID: 37478848
DOI: 10.1016/j.molcel.2023.06.023

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