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Article

Structures of flavivirus RNA promoters suggest two binding modes with NS5 polymerase

5 May 2021

Abstract excerpt

Flaviviruses use a ~70 nucleotide stem-loop structure called stem-loop A (SLA) at the 5' end of the RNA genome as a promoter for RNA synthesis. Flaviviral polymerase NS5 specifically recognizes SLA to initiate RNA synthesis and methylate the 5' guanosine cap. We report the crystal structures of dengue (DENV) and Zika virus (ZIKV) SLAs. DENV and ZIKV SLAs differ in the relative orientations of their top stem-loop...

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PMID: 33953197
DOI: 10.1038/s41467-021-22846-1

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