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Long non‐coding subgenomic flavivirus RNAs have extended 3D structures and are flexible in solution

10 Sept 2019

Abstract excerpt

Most mosquito-borne flaviviruses, including Zika virus (ZIKV), Dengue virus (DENV), and West Nile virus (WNV), produce long non-coding subgenomic RNAs (sfRNAs) in infected cells that link to pathogenicity and immune evasion. Until now, the structural characterization of these lncRNAs remains limited. Here, we studied the 3D structures of individual and combined subdomains of sfRNAs, and visualized the accessible...

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Identifiers

PMID: 31502753
DOI: 10.15252/embr.201847016

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