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Article

Complement factor I: Regulatory nexus, driver of immunopathology, and therapeutic.

Immunobiology - 1 Sept 2023

Hallam T M, Sharp S J, Andreadi A, Kavanagh D

Abstract excerpt

Complement factor I (FI) is the nexus for classical, lectin and alternative pathway complement regulation. FI is an 88 kDa plasma protein that circulates in an inactive configuration until it forms a trimolecular complex with its cofactor and substrate whereupon a structural reorganization allows the catalytic triad to cleave its substrates, C3b and C4b. In keeping with its role as the master complement...

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Identifiers

PMID: 37478687
DOI: 10.1016/j.imbio.2023.152410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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