Article
Structural basis for complement factor I control and its disease-associated sequence polymorphisms.
Proceedings of the National Academy of Sciences of the United States of America - 2 Aug 2011
Roversi Pietro, Johnson Steven, Caesar Joseph J E, McLean Florence, Leath Kirstin J, Tsiftsoglou Stefanos A, Morgan B Paul, Harris Claire L, Sim Robert B, Lea Susan M
Abstract excerpt
The complement system is a key component of innate and adaptive immune responses. Complement regulation is critical for prevention and control of disease. We have determined the crystal structure of the complement regulatory enzyme human factor I (fI). FI is in a proteolytically inactive form, demonstrating that it circulates in a zymogen-like state despite being fully processed to the mature sequence. Mapping of...
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