Article
European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management.
Journal of clinical immunology - 1 May 2020
Brodszki Nicholas, Frazer-Abel Ashley, Grumach Anete S, Kirschfink Michael, Litzman Jiri, Perez Elena, Seppänen Mikko R J, Sullivan Kathleen E, Jolles Stephen
Abstract excerpt
This guideline aims to describe the complement system and the functions of the constituent pathways, with particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system, the classical,...
Topics
- Autoimmune Diseases
- Complement System Proteins
- Disease Susceptibility
- Europe
- Genetic Testing
- Humans
- Infections
- Inflammation
- Mutation