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Article

Functional evaluation of complement factor I variants by immunoassays and SDS-PAGE.

Frontiers in immunology - 1 Jan 2023

Gerogianni Alexandra, Baas Laura M, Sjöström Dick J, van de Kar Nicole C A J, Pullen Marit, van de Peppel Siem J, Nilsson Per H, van den Heuvel Lambertus P

Abstract excerpt

Factor I (FI) is an essential regulator of the complement system. Together with co-factors, FI degrades C3b, which inhibits further complement activation. Genetic mutations in FI are associated with pathological conditions like age-related macular degeneration and atypical hemolytic uremic syndome. Here, we evaluated eight recombinant FI genetic variants found in patients. We assessed FI's co-factor activity in...

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Identifiers

PMID: 37954579
DOI: 10.3389/fimmu.2023.1279612
PMCID: PMC10639126

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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