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Article

Complement factor I in health and disease.

Molecular immunology - 1 Aug 2011

Nilsson Sara C, Sim Robert B, Lea Susan M, Fremeaux-Bacchi Veronique, Blom Anna M

Abstract excerpt

Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to degrade activated complement proteins C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1 or CD46. Complete deficiency of FI, which is synthesized mainly in the liver is rare and leads to complement consumption resulting in recurrent severe infections, glomerulonephritis...

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Source

Identifiers

PMID: 21529951
DOI: 10.1016/j.molimm.2011.04.004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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