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Article

Complement Dysregulation and Disease: Insights from Contemporary Genetics.

Annual review of pathology - 24 Jan 2017

Liszewski M Kathryn, Java Anuja, Schramm Elizabeth C, Atkinson John P

Abstract excerpt

The vertebrate complement system consists of sequentially interacting proteins that provide for a rapid and powerful host defense. Nearly 60 proteins comprise three activation pathways (classical, alternative, and lectin) and a terminal cytolytic pathway common to all. Attesting to its potency, nearly half of the system's components are engaged in its regulation. An emerging theme over the past decade is that...

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Identifiers

PMID: 27959629
DOI: 10.1146/annurev-pathol-012615-044145
PMCID: PMC6020056

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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