Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.

doi:10.1016/j.imbio.2012.07.021

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Complement dysregulation and disease: from genes and proteins to diagnostics and drugs.

Immunobiology - 1 Nov 2012

de Cordoba Santiago Rodriguez, Tortajada Agustin, Harris Claire L, Morgan B Paul

Abstract excerpt

During the last decade, numerous studies have associated genetic variations in complement components and regulators with a number of chronic and infectious diseases. The functional characterization of these complement protein variants, in addition to recent structural advances in understanding of the assembly, activation and regulation of the AP C3 convertase, have provided important insights into the pathogenic...

Topics

Complement Activation
Complement C3-C5 Convertases
Complement Inactivator Proteins
Complement System Proteins
Genetic Variation
Glomerulonephritis, Membranoproliferative
Hemolytic-Uremic Syndrome
Humans
Inflammation
Macular Degeneration

Source

Open in PubMed

Identifiers

PMID: 22964229
DOI: 10.1016/j.imbio.2012.07.021

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics