Article
The uncharacterized transcript KIAA0930 confers a cachexic phenotype on cancer cells.
Oncotarget - 20 Jul 2023
Yamakawa Takahiro, Zhang Guoxiang, Najjar Liza Bengrine, Li Chun, Itakura Keiichi
Abstract excerpt
Patients with cancer cachexia have a poor prognosis and impaired quality of life. Numerous studies using preclinical models have shown that inflammatory cytokines play an important role in the development of cancer cachexia; however, no clinical trial targeting cytokines has been successful. Therefore, it is essential to identify molecular mechanisms to develop anti-cachexia therapies. Here we identified the...
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