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Article

Beyond cancer: breast cancer gene 2 emerges as a new player in atherosclerosis.

American journal of physiology. Heart and circulatory physiology - 1 Aug 2026

Michels David C R, Singh Aman, Patel Margi, Rasheed Berk, Nikfarjam Sepideh, Bu Shuhan, Ehsan Mehroz, Feng Biao, German-Castelan Liliana, Gros Robert, Frisbee Jefferson C, Singh Krishna K

Abstract excerpt

Atherosclerosis is a chronic immunoinflammatory disease driven by endothelial dysfunction, oxidative stress, and DNA damage. Although breast cancer gene 2 (BRCA2) is a key regulator of homologous recombination-mediated DNA damage repair, its role in vascular biology remains unclear. We hypothesized that endothelial BRCA2 protects against atherogenesis under stress conditions. Endothelial-specific BRCA2 knockdown...

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Source

Identifiers

PMID: 42435432
DOI: 10.1152/ajpheart.00790.2025

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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