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Article

Design space determination to optimize DNA complexation and full capsid formation in transient rAAV manufacturing

21 Jul 2023

Abstract excerpt

Recombinant adeno-associated virus (rAAV) vectors are a promising platform for in vivo gene therapies. However, cost-effective, well-characterized processes necessary to manufacture rAAV therapeutics are challenging to develop without an understanding of how process parameters (PPs) affect rAAV product quality attributes (PQAs). In this work, a central composite orthogonal experimental design was employed to...

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PMID: 37475681
DOI: 10.1002/bit.28508

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