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High‐yield recombinant adeno‐associated viral vector production by multivariate optimization of bioprocess and transfection conditions

7 Mar 2024

Abstract excerpt

Abstract Recombinant adeno‐associated viral vectors (rAAVs) are one of the most used vehicles for gene therapy, with five rAAV therapeutics commercially approved by the FDA. To improve product yield, we optimized the suspension production process of rAAV8 vectors carrying a proprietary transgene using a commercially available transfection reagent, FectoVIR‐AAV. Using a miniaturized automated 250 mL scale...

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PMID: 38450973
DOI: 10.1002/btpr.3445

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