Article

Continuous Production of rAAV via an Intensified Transient Transfection Process

2024-09-22

Abstract excerpt

Increasing demand for recombinant adeno-associated virus (rAAV)-based gene therapies necessitates increased manufacturing production. Transient transfection of mammalian cells remains the most commonly used method to produce clinical-grade rAAVs due to its ease of implementation. However, transient transfection processes are often characterized by sub-optimal yields and low fractions of full-to-total capsids, both...

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Literature Corpus work: 94d1bfa1-e360-5562-a4d5-2aa96e9c8be3
DOI: 10.22541/au.172704244.48626142/v1

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