Article
TRAF3/STAT6 axis regulates macrophage polarization and tumor progression.
Cell death and differentiation - 1 Aug 2023
Shi Jian-Hong, Liu Li-Na, Song Dan-Dan, Liu Wen-Wen, Ling Chen, Wu Fei-Xiang, Wang Ting-Ting, Liu Bin, Cui Nai-Peng, Qin Yan, Ni Zhi-Yu
Abstract excerpt
Converting tumor-associated macrophages (TAMs) from the M2 to the M1 phenotype is considered an effective strategy for cancer therapy. TRAF3 is known to regulate NF-κB signaling. However, the role of TRAF3 in TAM polarization has not yet been completely elucidated. Here, we found that ablation of TRAF3 increased M1 markers, iNOS, FGR and SLC4A7, while down-regulated M2 markers, CD206, CD36 and ABCC3, expression...
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