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Article

ATF3 promotes migration and M1/M2 polarization of macrophages by activating tenascin‑C via Wnt/β‑catenin pathway.

Molecular medicine reports - 1 Sept 2017

Sha Hao, Zhang Dianzhong, Zhang Yunfei, Wen Yanhua, Wang Yucai

Abstract excerpt

There are different polarization states of macrophages, including the classically activated M1 phenotype and the alternatively activated M2 phenotype. These have different functions in the inflammation process. Activating transcription factor 3 (ATF3) is a key transcriptional regulator that inhibits the inflammatory response. However, the effects of ATF3 on migration and anti‑inflammatory control mechanisms of...

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Source

Identifiers

PMID: 28714032
DOI: 10.3892/mmr.2017.6992

Genes

ATF3
TNC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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