Article
SHISA3 Reprograms Tumor-Associated Macrophages Toward an Antitumoral Phenotype and Enhances Cancer Immunotherapy.
Advanced science (Weinheim, Baden-Wurttemberg, Germany) - 1 Sept 2024
Zhang Shimeng, Yu Bingbing, Sheng Chunjie, Yao Chen, Liu Yang, Wang Jing, Zeng Qi, Mao Yizhi, Bei Jinxin, Zhu Bin, Chen Shuai
Abstract excerpt
The main challenge for immune checkpoint blockade (ICB) therapy lies in immunosuppressive tumor microenvironment (TME). Repolarizing M2-like tumor-associated macrophages (TAMs) into inflammatory M1 phenotype is a promising strategy for cancer immunotherapy. Here, this study shows that the tumor suppressive protein SHISA3 regulates the antitumor functions of TAMs. Local delivery of mRNA encoding Shisa3 enables...
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