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Article

MFHAS1 promotes colorectal cancer progress by regulating polarization of tumor-associated macrophages via STAT6 signaling pathway.

Oncotarget - 29 Nov 2016

Chen Wankun, Xu Yajun, Zhong Jing, Wang Huihui, Weng Meilin, Cheng Qian, Wu Qichao, Sun Zhirong, Jiang Hui, Zhu Minmin, Ren Yu, Xu Pingbo, Chen Jiawei, Miao Changhong

Abstract excerpt

Malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) is a predicted oncoprotein that demonstrates tumorigenic activity in vivo; however, the mechanisms involved are unknown. Macrophages are divided into the pro-inflammatory M1 and anti-inflammatory/protumoral M2 subtypes. Tumor cells can induce M2 polarization of tumor-associated macrophages (TAMs) to promote metastasis; but the underlying pathways...

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Source

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Identifiers

PMID: 27783989
DOI: 10.18632/oncotarget.12807
PMCID: PMC5346672

Genes

MFHAS1
STAT6
KLF4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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