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TRAF6 regulates the signaling pathway influencing colorectal cancer function through ubiquitination mechanisms

18 Feb 2022

Abstract excerpt

Tumor necrosis factor receptor-associated factor-6 (TRAF6) is a ubiquitin E3 ligase. TRAF6 plays an important role in tumor invasion and metastasis. However, the specific mechanism by which TRAF6 promotes colorectal cancer (CRC) metastasis is incompletely understood. This study aimed to determine whether TRAF6 affects the LPS-NF-κB-VEGF-C signaling pathway through ubiquitination, which plays a role in colorectal...

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PMID: 35179811
DOI: 10.1111/cas.15302

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