Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli.

The Journal of clinical investigation - 1 Jun 2004

Peterson Karin S, Huang Jing-Feng, Zhu Jessica, D'Agati Vivette, Liu Xuejun, Miller Nancy, Erlander Mark G, Jackson Michael R, Winchester Robert J

Abstract excerpt

The molecular pathogenesis of focal/diffuse proliferative lupus glomerulonephritis was studied by cDNA microarray analysis of gene expression in glomeruli from clinical biopsies. Transcriptional phenotyping of glomeruli isolated by laser-capture microscopy revealed considerable kidney-to-kidney heterogeneity in increased transcript expression, resulting in four main gene clusters that identified the presence of B...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biopsy
Share to Kidney Glomerulus

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lasers

Share to Lupus Nephritis

Share to Multigene Family

Share to Oligonucleotide Array Sequence Analysis

Share to Regression Analysis

Share to Transcription, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 15199407
DOI: 10.1172/JCI19139
PMCID: PMC420500

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruli.PMID 15199407Read ↗

Characterization of heterogeneity in the molecular pathogenesis of lupus nephritis from transcriptional profiles of laser-captured glomeruliSemantic proximity Read ↗

Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathwaysSemantic proximity Read ↗

The spatially resolved transcriptome signatures of glomeruli in chronic kidney diseaseSemantic proximity Read ↗

Intrarenal myeloid subsets associated with kidney injury are comparable in mice and patients with lupus nephritisSemantic proximity Read ↗

Insights from Comparison of the Renal and Skin Single Cell Transcriptomes in Lupus NephritisSemantic proximity Read ↗

Spatial proteomics landscape and immune signature analysis of renal sample of lupus nephritis based on laser-captured microsectionSemantic proximity Read ↗

Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney DiseaseSemantic proximity Read ↗

Deep profiling of lupus nephritis kidneys reveals dynamic changes in myeloid cells associated with disease progressionSemantic proximity Read ↗

Comprehensive single-cell transcriptional profiling defines shared and unique epithelial injury responses during kidney fibrosisSemantic proximity Read ↗

A protocol for single-cell transcriptomics from cryopreserved renal tissue and urine for the Accelerating Medicine Partnership (AMP) RA/SLE networkSemantic proximity Read ↗

Damaged glomeruli in proliferative pediatric lupus nephritis exhibit a C5a-C5aR1 induced fibrotic transcriptional programSemantic proximity Read ↗

Single cell RNA sequencing to dissect the molecular heterogeneity in lupus nephritisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.