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Article

Association between genetic variations in surfactant protein d and emphysema, interstitial pneumonia, and lung cancer in a Japanese population.

COPD - 1 Aug 2012

Ishii Takeo, Hagiwara Koichi, Ikeda Shinobu, Arai Tomio, Mieno Makiko Naka, Kumasaka Toshio, Muramatsu Masaaki, Sawabe Motoji, Gemma Akihiko, Kida Kozui

Abstract excerpt

Surfactant protein D (SFTPD) is a lung-specific anti-inflammatory factor that antagonizes inflammation by inhibiting oxidative stress and stimulating innate immunity. Variations in SFTPA2 and SFTPB, genes for other surfactant proteins, have been associated with lung cancer. We therefore investigated associations between SFTPD variations and lung cancer as well as emphysema and interstitial pneumonia, which are...

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Identifiers

PMID: 22509983
DOI: 10.3109/15412555.2012.676110

Genes

SFTPD
SFTPA2
SFTPB

Provenance

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