Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rare SP-A alleles and the SP-A1-6A(4) allele associate with risk for lung carcinoma.

Clinical genetics - 1 Aug 2005

Seifart C, Lin H-M, Seifart U, Plagens A, DiAngelo S, von Wichert P, Floros J

Abstract excerpt

Next to cigarette smoking, genetic factors may contribute to lung cancer risk. Pulmonary surfactant components may mediate response to inhaled carcinogenic substances and/or play a role in lung function and inflammation. We studied associations between surfactant protein (SP) genetic variants and risk in lung cancer subgroups. Samples (n=308) were genotyped for SP-A1, -A2, -B, and -D marker alleles. These...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over
Share to Carcinoma, Non-Small-Cell Lung
Share to Carcinoma, Small Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Case-Control Studies

Share to Genetic Markers

Share to Lung Neoplasms

Share to Polymorphism, Restriction Fragment Length

Share to Pulmonary Surfactant-Associated Protein A

Source

Identifiers

PMID: 15996209
DOI: 10.1111/j.1399-0004.2005.00470.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rare SP-A alleles and the SP-A1-6A(4) allele associate with risk for lung carcinoma.PMID 15996209Read ↗

High risk of lung cancer in surfactant-related gene variant carriers.Semantic proximity Read ↗

Genetic variant associations of human SP-A and SP-D with acute and chronic lung injury.Semantic proximity Read ↗

Surfactant protein B gene variations enhance susceptibility to squamous cell carcinoma of the lung in German patients.Semantic proximity Read ↗

Candidate pathway analysis of surfactant proteins identifies CTSH and SFTA2 that influences lung cancer risk.Semantic proximity Read ↗

Functional polymorphisms in surfactant protein genes and chronic obstructive pulmonary disease risk: a meta-analysis.Semantic proximity Read ↗

Genetic Diversity of Human SP-A, a Molecule with Innate host Defense and Surfactant-Related Functions; Characteristics, Primary Function, and Significance.Semantic proximity Read ↗

Surfactant proteins as genetic determinants of multifactorial pulmonary diseases.Semantic proximity Read ↗

Surfactant protein A and B genetic variants predispose to idiopathic pulmonary fibrosis.Semantic proximity Read ↗

Surfactant protein D is a causal risk factor for COPD: results of Mendelian randomisation.Semantic proximity Read ↗

Surfactant protein polymorphisms and neonatal lung disease.Semantic proximity Read ↗

Human Surfactant Protein SP-A1 and SP-A2 Variants Differentially Affect the Alveolar Microenvironment, Surfactant Structure, Regulation and Function of the Alveolar Macrophage, and Animal and Human Survival Under Various Conditions.Semantic proximity Read ↗

Association between genetic variations in surfactant protein d and emphysema, interstitial pneumonia, and lung cancer in a Japanese population.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.