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Lenvatinib recruits cytotoxic GZMK+CD8 T cells in hepatocellular carcinoma

17 Jul 2023

Abstract excerpt

BACKGROUND: Lenvatinib was expected to enhance the effect of immune checkpoint inhibitors (ICIs) for unresectable HCC; however, their combination therapy failed to show the synergy in the phase III clinical trial. METHODS: To elucidate lenvatinib-induced molecular modulation, we performed bulk RNA-sequencing and digital spatial profiling of 5 surgically resected human HCC specimens after lenvatinib treatment and...

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PMID: 37471053
DOI: 10.1097/hc9.0000000000000209

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