Article

NK cells contribute to resistance to anti-PD1 therapy in immune-excluded melanomas

2023-12-14

Abstract excerpt

Immune checkpoint blockade (ICB) has become a standard of care in the treatment of metastatic melanoma (MM). Although ICB is particularly successful in some MM patients, more than half do not obtain a durable benefit. Biomarkers that predict response are urgently needed and overcoming intrinsic resistance is key to improving the success of ICB therapy. Using single cell RNA sequencing, we characterized the immune...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 1bbbaef7-0990-5a63-912d-4c356796be0a
DOI: 10.1101/2023.12.14.571631

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

NK cells contribute to resistance to anti-PD1 therapy in immune-excluded melanomasDOI 10.1101/2023.12.14.571631Read

Integrating tumor and immune cell transcriptomics to predict immune checkpoint inhibitor primary resistance in metastatic cutaneous melanomaSemantic proximity Read

Cellular and spatial continuum of TAM functional states governs immune exclusion and dictates immune checkpoint resistance in melanomaSemantic proximity Read

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanomaSemantic proximity Read

Multimodal blood based profiling reveals insights into mechanisms of immunotherapy resistanceSemantic proximity Read

High IGKC Expressing Intratumoral Plasma Cells Predict Response to Immune Checkpoint BlockadeSemantic proximity Read

Deep sequencing of the T cell Receptor reveals common and reproducible CD8 <sup>+</sup> signatures of response to checkpoint immunotherapySemantic proximity Read

Comprehensive immune profiling of melanoma-draining lymph nodes identifies plasmacytoid dendritic cells as new biomarker for PD-L1 blockadeSemantic proximity Read

Harnessing Inflammatory Monocytes to Overcome Resistance to Anti-PD-1 ImmunotherapySemantic proximity Read

Mature and migratory dendritic cells promote immune infiltration and response to anti-PD-1 checkpoint blockade in metastatic melanomaSemantic proximity Read

Single-cell analysis reveals new evolutionary complexity in uveal melanomaSemantic proximity Read

Identification of tumor-intrinsic drivers of immune exclusion in acral melanomaSemantic proximity Read

A Comprehensive Proteogenomic and Spatial Analysis of Innate and Acquired Resistance of Metastatic Melanoma to Immune Checkpoint Blockade TherapiesSemantic proximity Read