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Article

Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease.

Journal of gastroenterology - 1 Mar 2018

Seko Yuya, Yamaguchi Kanji, Mizuno Naoki, Okuda Keiichiro, Takemura Masashi, Taketani Hiroyoshi, Hara Tasuku, Umemura Atsushi, Nishikawa Taichiro, Moriguchi Michihisa, Yasui Kohichiroh, Kamaguchi Mai, Nishioji Kenichi, Mochizuki Naomi, Kobayashi Masao, Mori Kojiroh, Tanaka Saiyu, Matsuura Kentaro, Tanaka Yasuhito, Itoh Yoshito

Abstract excerpt

BACKGROUND: Hepatic fibrosis is an independent risk factor for mortality and liver-related events in patients with nonalcoholic fatty liver disease (NAFLD). PNPLA3 rs738409 has been associated with fibrosis in viral and non-viral hepatitis. TLL1 rs17047200 also has been associated with developing hepatocellular carcinoma probably via hepatic fibrogenesis. We estimated the impact of these genetic polymorphisms on...

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Share to Aspartate Aminotransferases
Share to Body Mass Index
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Share to Liver Cirrhosis
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Share to Serum Albumin
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Source

Identifiers

PMID: 28744823
DOI: 10.1007/s00535-017-1372-8

Genes

PNPLA3
TLL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Combination of PNPLA3 and TLL1 polymorphism can predict advanced fibrosis in Japanese patients with nonalcoholic fatty liver disease.PMID 28744823Read ↗

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