Article
Definitive evidence for Club cells as progenitors for mutant Kras/Trp53-deficient lung cancer.
International journal of cancer - 1 Nov 2021
Rosigkeit Sebastian, Kruchem Marie, Thies Dorothe, Kreft Andreas, Eichler Emma, Boegel Sebastian, Jansky Sandrine, Siegl Dominik, Kaps Leonard, Pickert Geethanjali, Haehnel Patricia, Kindler Thomas, Hartwig Udo F, Guerra Carmen, Barbacid Mariano, Schuppan Detlef, Bockamp Ernesto
Abstract excerpt
Accumulating evidence suggests that both the nature of oncogenic lesions and the cell-of-origin can strongly influence cancer histopathology, tumor aggressiveness and response to therapy. Although oncogenic Kras expression and loss of Trp53 tumor suppressor gene function have been demonstrated to initiate murine lung adenocarcinomas (LUADs) in alveolar type II (AT2) cells, clear evidence that Club cells,...
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