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Article

Genome-Wide Association Study in Acute Tubulointerstitial Nephritis.

Journal of the American Society of Nephrology : JASN - 1 May 2023

Zhou Xu-Jie, Su Tao, Xie Jingyuan, Xie Qiong-Hong, Wang Li-Zhong, Hu Yong, Chen Gang, Jia Yan, Huang Jun-Wen, Li Gui, Liu Yang, Yu Xiao-Juan, Nath Swapan K, Tsoi Lam C, Patrick Matthew T, Berthier Celine C, Liu Gang, Wang Su-Xia, Xu Huji, Chen Nan, Hao Chuan-Ming, Zhang Hong, Yang Li

Abstract excerpt

SIGNIFICANCE STATEMENT: Polymorphisms of HLA genes may confer susceptibility to acute tubulointerstitial nephritis (ATIN), but small sample sizes and candidate gene design have hindered their investigation. The first genome-wide association study of ATIN identified two significant loci, risk haplotype DRB1*14-DQA1*0101-DQB1*0503 (DR14 serotype) and protective haplotype DRB1*1501-DQA1*0102-DQB1*0602 (DR15...

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Identifiers

PMID: 36749126
DOI: 10.1681/ASN.0000000000000091
PMCID: PMC10125656

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