Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.

doi:10.1371/journal.pone.0233464

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Article

Variants in IL23R-C1orf141 and ADO-ZNF365-EGR2 are associated with susceptibility to Vogt-Koyanagi-Harada disease in Japanese population.

PloS one - 1 Jan 2020

Sakono Takuto, Meguro Akira, Takeuchi Masaki, Yamane Takahiro, Teshigawara Takeshi, Kitaichi Nobuyoshi, Horie Yukihiro, Namba Kenichi, Ohno Shigeaki, Nakao Kumiko, Sakamoto Taiji, Sakai Tsutomu, Nakano Tadashi, Keino Hiroshi, Okada Annabelle A, Takeda Atsunobu, Ito Takako, Mashimo Hisashi, Ohguro Nobuyuki, Oono Shinichirou, Enaida Hiroshi, Okinami Satoshi, Horita Nobuyuki, Ota Masao, Mizuki Nobuhisa

Abstract excerpt

Vogt-Koyanagi-Harada (VKH) disease is a systemic inflammatory disorder that affects pigment cell-containing organs such as the eye (e.g., chronic and/or recurrent granulomatous panuveitis). While the exact etiology and pathogenic mechanism of VKH disease are unclear, HLA-DR4 alleles have been documented to be strongly associated with VKH disease in various ethnic groups. Recently, a genome-wide association study...

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PMID: 32437414
DOI: 10.1371/journal.pone.0233464
PMCID: PMC7241744

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