Article

PCCA variant rs16957301 is a novel AKI risk genotype-specific for patients who receive ICI treatment: Real-world evidence from All of Us cohort

2024-06-20

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Immune checkpoint inhibitors (ICIs) enhance the immune system’s ability to target and destroy cancer cells by blocking inhibitory pathways. Despite their efficacy, these treatments can trigger immune-related adverse events (irAEs), such as acute kidney injury (ICI-AKI), complicating patient management. The genetic predispositions to ICI-AKI are not well understood, necessita...

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Literature Corpus work: b2c63721-9b03-57ca-9b55-ea4540812748
DOI: 10.1101/2024.06.20.24309197

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PCCA variant rs16957301 is a novel AKI risk genotype-specific for patients who receive ICI treatment: Real-world evidence from All of Us cohortDOI 10.1101/2024.06.20.24309197Read

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