Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging

Abstract excerpt

Autoreactive encephalitogenic T cells exist in the healthy immune repertoire but need a trigger to induce CNS inflammation. The underlying mechanisms remain elusive, whereby microbiota were shown to be involved in the manifestation of CNS autoimmunity. Here, we used intravital imaging to explore how microbiota affect the T cells as trigger of CNS inflammation. Encephalitogenic CD4 + T cells transduced with the...

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