M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

doi:10.1073/pnas.2506550123

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Article

M cell-dependent commensal uptake confers encephalitogenic phenotypes on γδT17 cells in Peyer's patches.

Proceedings of the National Academy of Sciences of the United States of America - 13 Jan 2026

Komiyama Seiga, Kodaira Yotaro, Maeda Rae, Sugiura Yuki, Suzuki Koichiro, Saeki Aiko, Kinashi Yusuke, Oguchi Hiroyuki, Takano Kokona, Onawa Satoshi, Matsui Ako, Sasaki Eita, Hattori-Muroi Kisara, Kimura Shunsuke, Fujimura Yumiko, Ka Yuyo, Ogura Tomoyuki, Hanaoka Kenjiro, Ito Minako, Watarai Hiroshi, Kaisho Tsuneyasu, Udagawa Nobuyuki, Takahashi Daisuke, Hase Koji

Abstract excerpt

Interleukin-17-producing γδT cells (γδT17 cells) play a dual role in immune regulation, serving as both protectors in various tissues and orchestrators of inflammatory responses in autoimmune diseases, including experimental autoimmune encephalomyelitis (EAE), a rodent model of multiple sclerosis. However, the ontology and repertoires of encephalitogenic γδT17 cells remain unclear. In this study, we demonstrate...

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Identifiers

PMID: 41512014
DOI: 10.1073/pnas.2506550123
PMCID: PMC12799176

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