Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 2006

Reinhardt R Lee, Hong Seokmann, Kang Suk-Jo, Wang Zhi-en, Locksley Richard M

Abstract excerpt

IL-12p40 is induced in macrophages and dendritic cells (DC) after activation by microbial TLR ligands and cytokines and constitutes a component of IL-12 and IL-23. In an effort to understand the location and kinetics of these cytokines during the course of an immune response, we generated knockin (gene-targeted) mice that express the p40 gene linked via a viral internal ribosome entry site element with...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Interleukin-23
Share to Interleukin-12

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-12 Subunit p40

Share to Interleukins

Share to Lymph Nodes

Share to Macrophages, Peritoneal

Share to Th1 Cells

Share to Toll-Like Receptors

Source

Identifiers

PMID: 16849470
DOI: 10.4049/jimmunol.177.3.1618

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation.PMID 16849470Read ↗

Constitutive p40 promoter activation and IL-23 production in the terminal ileum mediated by dendritic cellsSemantic proximity Read ↗

A fluorescence reporter model defines "Tip-DCs" as the cellular source of interferon β in murine listeriosis.Semantic proximity Read ↗

IL-22 Fate Reporter Reveals Origin and Control of IL-22 Production in Homeostasis and InfectionSemantic proximity Read ↗

Impaired Th1 responses in mice deficient in Epstein‐Barr virus‐induced gene 3 and challenged with physiological doses of <i>Leishmania major</i>Semantic proximity Read ↗

Dendritic cell-derived IL-12p40 homodimer contributes to susceptibility in cutaneous leishmaniasis in BALB/c mice.Semantic proximity Read ↗

Salmonella typhimurium infection triggers dendritic cells and macrophages to adopt distinct migration patterns in vivo.Semantic proximity Read ↗

In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice.Semantic proximity Read ↗

iNOS-producing inflammatory dendritic cells constitute the major infected cell type during the chronic Leishmania major infection phase of C57BL/6 resistant mice.Semantic proximity Read ↗

Cutting Edge: The direct action of type I IFN on CD4 T cells is critical for sustaining clonal expansion in response to a viral but not a bacterial infection.Semantic proximity Read ↗

Two waves of antigen‐containing dendritic cells <i>in vivo</i> in experimental <i>Leishmania major</i> infectionSemantic proximity Read ↗

Human Dendritic Cells Exhibit a Pronounced Type I IFN Signature following Leishmania major Infection That Is Required for IL-12 InductionSemantic proximity Read ↗

IL-12 family members: differential kinetics of their TLR4-mediated induction by Salmonella Enteritidis and the impact of IL-10 in bone marrow-derived macrophagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.