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Article

The gut-brain connection: triggering of brain autoimmune disease by commensal gut bacteria.

Rheumatology (Oxford, England) - 1 Dec 2016

Wekerle Hartmut

Abstract excerpt

In a transgenic model of spontaneous experimental autoimmune encephalomyelitis, autoimmune attack against the CNS requires the presence of an intact commensal gut flora. Extending this observation to human autoimmune disease, such as multiple sclerosis, we postulate that the pathogenic reaction requires the coincidence of at least three factors: a permissive genetic disposition, a pro-inflammatory intestinal...

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Source

Identifiers

PMID: 27856664
DOI: 10.1093/rheumatology/kew353

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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