Article
Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network.
Cell death & disease - 21 Mar 2026
Qian Rui, Zhao Zhipeng, Sun Xuanxuan, Xin Benkai, An Peipei, Yang Ting, Wu Ning, Hu Xin, Wan Youzhong
Abstract excerpt
Nuclear actin filament is required for efficient repair of DNA double-strand breaks. While cancer-associated SF3B1 mutation leads to impaired DNA repair, the underlying mechanism remains elusive. Here, we found that SF3B1 mutation led to defective nuclear actin network during DNA repair. Mechanistically, SF3B1 mutation increased the expression of circATP9B, which interacted with and facilitated the degradation of...
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