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Article

Epigenetic age acceleration and risk of aortic valve stenosis: a bidirectional Mendelian randomization study

12 Mar 2024

Abstract excerpt

BACKGROUND: Aortic valve stenosis (AVS) is the most prevalent cardiac valve lesion in developed countries, and pathogenesis is closely related to aging. DNA methylation-based epigenetic clock is now recognized as highly accurate predictor of the aging process and associated health outcomes. This study aimed to explore the causal relationship between epigenetic clock and AVS by conducting a bidirectional Mendelian...

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PMID: 38475866
DOI: 10.1186/s13148-024-01647-5

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