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Article

The bidirectional association between frailty index and cardiovascular disease: A Mendelian randomization study.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 Mar 2024

Xu Qingyun, Jia Yiming, Wang Yinan, Yang Pinni, Sun Lulu, Liu Yi, Chang Xinyue, He Yu, Guo Daoxia, Shi Mengyao, Zhang Yonghong, Zhu Zhengbao

Abstract excerpt

BACKGROUND AND AIM: Observational studies have suggested a relationship between frailty and cardiovascular disease (CVD), but the causality is still uncertain. We used bidirectional Mendelian randomization (MR) design to investigate the potential causal associations between frailty and four main CVDs, including hypertension, myocardial infarction (MI), heart failure (HF), and atrial fibrillation (AF). METHODS AND...

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Identifiers

PMID: 38176958
DOI: 10.1016/j.numecd.2023.10.018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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