Article
The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders.
Molecular psychiatry - 1 Feb 2018
Chang H, Hoshina N, Zhang C, Ma Y, Cao H, Wang Y, Wu D-D, Bergen S E, Landén M, Hultman C M, Preisig M, Kutalik Z, Castelao E, Grigoroiu-Serbanescu M, Forstner A J, Strohmaier J, Hecker J, Schulze T G, Müller-Myhsok B, Reif A, Mitchell P B, Martin N G, Schofield P R, Cichon S, Nöthen M M, Walter H, Erk S, Heinz A, Amin N, van Duijn C M, Meyer-Lindenberg A, Tost H, Xiao X, Yamamoto T, Rietschel M, Li M
Abstract excerpt
Major mood disorders, which primarily include bipolar disorder and major depressive disorder, are the leading cause of disability worldwide and pose a major challenge in identifying robust risk genes. Here, we present data from independent large-scale clinical data sets (including 29 557 cases and 32 056 controls) revealing brain expressed protocadherin 17 (PCDH17) as a susceptibility gene for major mood...
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