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Long-Term Organ Culture Reveals Differential Stem Cell–Driven Remodeling in Myometrium and <i>MED12</i> -Mutant Uterine Leiomyoma

2025-08-22

Abstract excerpt

<h4>ABSTRACT</h4> Uterine leiomyomas or fibroids are highly prevalent benign tumors of the female reproductive tract, often causing significant symptoms and requiring surgical intervention, leading to substantial healthcare costs worldwide. Their molecular pathogenesis remains incompletely understood, but evidence suggests that somatic stem cells play a pivotal role in myometrial growth, whereas a genetic alterat...

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Literature Corpus work: a65c1248-a95a-51a0-91b5-3153df48e4a1
DOI: 10.1101/2025.08.19.670360

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