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Article

Effects of putative metformin targets on phenotypic age and leukocyte telomere length: a mendelian randomisation study using data from the UK Biobank

1 Jul 2023

Abstract excerpt

Background Metformin, a first-line medication for type 2 diabetes, might also have a protective effect against ageing-related diseases, but so far little experimental evidence is available. We sought to assess the target-specific effect of metformin on biomarkers of ageing in the UK Biobank. Methods In this drug target mendelian randomisation study, we assessed the target-specific effect of four putative targets...

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Share to Genetics, Aging, and Longevity in Model Organisms
Share to Metabolism, Diabetes, and Cancer
Share to Telomeres, Telomerase, and Senescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 37421961
DOI: 10.1016/s2666-7568(23)00085-5

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