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The effect of metformin on urate metabolism: Findings from observational and Mendelian randomization analyses.

Diabetes, obesity & metabolism - 1 Jan 2024

Dai Huajie, Hou Tianzhichao, Wang Qi, Zhu Zheng, Zhu Yijie, Zhao Zhiyun, Li Mian, Xu Yu, Lu Jieli, Wang Tiange, Ning Guang, Wang Weiqing, Bi Yufang, Zheng Jie, Xu Min

Abstract excerpt

AIM: To evaluate the effect of metformin on urate metabolism. MATERIALS AND METHODS: Using the UK Biobank, we first performed association analyses of metformin use with urate levels, risk of hyperuricaemia and incident gout in patients with diabetes. To explore the causal effect of metformin on urate and gout, we identified genetic variants proxying the glycated haemoglobin (HbA1c)-lowering effect of metformin...

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PMID: 37807832
DOI: 10.1111/dom.15310

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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