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Article

Impact of glycemic traits, type 2 diabetes and metformin use on breast and prostate cancer risk: a Mendelian randomization study.

BMJ open diabetes research & care - 1 Jan 2019

Au Yeung Shiu Lun, Schooling Catherine Mary

Abstract excerpt

Objectives: Observational studies suggest glycemic traits and type 2 diabetes are positively associated, and metformin inversely associated with breast and prostate cancer risk. However, observational studies are susceptible to unmeasured confounding while studies of metformin use are also vulnerable to immortal time bias. The use of Mendelian randomization may reduce confounding due to random allocation of...

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Identifiers

PMID: 31908803
DOI: 10.1136/bmjdrc-2019-000872
PMCID: PMC6936416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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