Article
Efficacy of metformin targets on cardiometabolic health in the general population and non-diabetic individuals: a Mendelian randomization study.
EBioMedicine - 1 Oct 2023
Zheng Jie, Xu Min, Yang Qian, Hu Chunyan, Walker Venexia, Lu Jieli, Wang Jiqiu, Liu Ruixin, Xu Yu, Wang Tiange, Zhao Zhiyun, Yuan Jinqiu, Burgess Stephen, Au Yeung Shiu Lun, Luo Shan, Anderson Emma L, Holmes Michael V, Smith George Davey, Ning Guang, Wang Weiqing, Gaunt Tom R, Bi Yufang
Abstract excerpt
BACKGROUND: Metformin shows beneficial effects on cardiometabolic health in diabetic individuals. However, the beneficial effects in the general population, especially in non-diabetic individuals are unclear. We aim to estimate the effects of perturbation of seven metformin targets on cardiometabolic health using Mendelian randomization (MR). METHODS: Genetic variants close to metformin-targeted genes associated...
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