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Programmed necroptosis is upregulated in low-grade myelodysplastic syndromes and may play a role in the pathogenesis

24 Sept 2021

Abstract excerpt

Myelodysplastic syndrome (MDS) is characterized by persistent cytopenias and evidence of morphologic dysplasia in the bone marrow (BM). Excessive hematopoietic programmed cell death (PCD) and inflammation have been observed in the bone marrow of patients with MDS, and are thought to play a significant role in the pathogenesis of the disease. Necroptosis is a major pathway of PCD that incites inflammation;...

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PMID: 34563605
DOI: 10.1016/j.exphem.2021.09.004

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