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Article

Heterogeneous expression of cytokines accounts for clinical diversity and refines prognostication in CMML.

Leukemia - 1 Jan 2019

Niyongere Sandrine, Lucas Nolwenn, Zhou Jun-Min, Sansil Samer, Pomicter Anthony D, Balasis Maria E, Robinson John, Kroeger Jodi, Zhang Qing, Zhao Yu Long, Ball Markus, Komrokji Rami, List Alan, Deininger Michael W, Fridley Brooke L, Santini Valeria, Solary Eric, Padron Eric

Abstract excerpt

Chronic myelomonocytic leukemia (CMML) is a clinically heterogeneous neoplasm in which JAK2 inhibition has demonstrated reductions in inflammatory cytokines and promising clinical activity. We hypothesize that annotation of inflammatory cytokines may uncover mutation-independent cytokine subsets associated with novel CMML prognostic features. A Luminex cytokine profiling assay was utilized to profile...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30026572
DOI: 10.1038/s41375-018-0203-0
PMCID: PMC7787307

Genes

ASXL1
CCL2
HGF
JAK2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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