Article
Transcriptome-wide association study identifies novel candidate susceptibility genes for migraine.
HGG advances - 13 Jul 2023
Meyers Travis J, Yin Jie, Herrera Victor A, Pressman Alice R, Hoffmann Thomas J, Schaefer Catherine, Avins Andrew L, Choquet Hélène
Abstract excerpt
Genome-wide association studies (GWASs) have identified more than 130 genetic susceptibility loci for migraine; however, how most of these loci impact migraine development is unknown. To identify novel genes associated with migraine and interpret the transcriptional products of those genes, we conducted a transcriptome-wide association study (TWAS). We performed tissue-specific and multi-tissue TWAS analyses to...
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