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Unveiling migraine subtype heterogeneity and risk loci: integrated genome-wide association study and single-cell transcriptomics discovery

18 Aug 2025

Abstract excerpt

BACKGROUND: Migraine, a debilitating neurological disorder with distinct subtypes (migraine with aura [MA] and migraine without aura [MO]), exhibits genetic and spatial heterogeneity that remains poorly understood. While genetic correlations between subtypes are established, spatially resolved molecular mechanisms driving their divergent clinical phenotypes-particularly in tissue microenvironments-are unclear,...

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PMID: 40826382
DOI: 10.1186/s10194-025-02128-7

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