Article
Genome-wide analysis of 102,084 migraine cases identifies 123 risk loci and subtype-specific risk alleles.
Nature genetics - 1 Feb 2022
Hautakangas Heidi, Winsvold Bendik S, Ruotsalainen Sanni E, Bjornsdottir Gyda, Harder Aster V E, Kogelman Lisette J A, Thomas Laurent F, Noordam Raymond, Benner Christian, Gormley Padhraig, Artto Ville, Banasik Karina, Bjornsdottir Anna, Boomsma Dorret I, Brumpton Ben M, Burgdorf Kristoffer Sølvsten, Buring Julie E, Chalmer Mona Ameri, de Boer Irene, Dichgans Martin, Erikstrup Christian, Färkkilä Markus, Garbrielsen Maiken Elvestad, Ghanbari Mohsen, Hagen Knut, Häppölä Paavo, Hottenga Jouke-Jan, Hrafnsdottir Maria G, Hveem Kristian, Johnsen Marianne Bakke, Kähönen Mika, Kristoffersen Espen S, Kurth Tobias, Lehtimäki Terho, Lighart Lannie, Magnusson Sigurdur H, Malik Rainer, Pedersen Ole Birger, Pelzer Nadine, Penninx Brenda W J H, Ran Caroline, Ridker Paul M, Rosendaal Frits R, Sigurdardottir Gudrun R, Skogholt Anne Heidi, Sveinsson Olafur A, Thorgeirsson Thorgeir E, Ullum Henrik, Vijfhuizen Lisanne S, Widén Elisabeth, van Dijk Ko Willems, Aromaa Arpo, Belin Andrea Carmine, Freilinger Tobias, Ikram M Arfan, Järvelin Marjo-Riitta, Raitakari Olli T, Terwindt Gisela M, Kallela Mikko, Wessman Maija, Olesen Jes, Chasman Daniel I, Nyholt Dale R, Stefánsson Hreinn, Stefansson Kari, van den Maagdenberg Arn M J M, Hansen Thomas Folkmann, Ripatti Samuli, Zwart John-Anker, Palotie Aarno, Pirinen Matti
Abstract excerpt
Migraine affects over a billion individuals worldwide but its genetic underpinning remains largely unknown. Here, we performed a genome-wide association study of 102,084 migraine cases and 771,257 controls and identified 123 loci, of which 86 are previously unknown. These loci provide an opportunity to evaluate shared and distinct genetic components in the two main migraine subtypes: migraine with aura and...
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